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Presented by: UT El Paso / Austin Cooperative Pharmacy Program & Paso del Norte Health Foundation

Gotu Kola


Compilation by Armando Gonzalez Stuart, PhD.
Gotu Kola

Scientific Name:

Centella asiatica

Botanical Family:

Apiaceae

Other Common Name:

Brahmi*, Indian pennywort, hydrocotyle, manduki, manduka-parni, Madekassol, spadeleaf, centella, ji xue cao, thankuni
*In India, the common name “Brahmi” is also used to designate a very different plant, Bacopa monnieri - Plantaginaceae.

Where is it found?

Gotu Kola is probably native to Southern Asia, and grows in marshy or wet habitats in Madagascar, India, Sri Lanka, China, and Mexico, as well as in certain areas of South America and South Africa.

Parts of the plant used:

Mainly the leaves and stems, although the root is sometimes used.

How is it used?

The plant is edible and the juice may be taken with milk. The herb can be fried in clarified butter. The powdered herb can be mixed water or sesame oil is applied externally for eczema, psoriasis and other skin conditions (Khare, 2004). Gotu kola is commercially available in capsules, pills, extracts, and ointments. In Mexico, the plant is decocted in water and taken internally to improve venous circulation and for weight loss (Mendoza-Castelán and Lugo-Pérez, 2011).

What is it used for?

In both China and India, Gotu kola has a reputation as an anti-aging remedy as well as to improve memory. The plant possesses anabolic, antiepileptic, nootropic, vulnerary, anti-inflammatory, antifibrotic, antitumor, adaptogeninc (helps adapt against various types of stress), venotonic (helps venous circulation) and depurative effects. Research with Gotu Kola has shown that it is useful in chronic venous insufficiency (CVI), microangiopathies in type 2 diabetes, and keloids (Vohora and Vohora, 2016; Bone and Mills, 2013; Quattrocchi, 2012).
In the ancient medical systems of India, mainly Siddha and Ayurveda, the plant is used to improve cognitive functions, against liver fibrosis, to stabilize atherosclerotic plaque, and as an anxiolytic (to decrease anxiety). This species is also used externally and internally for leprosy and scleroderma. For external application it is used for psoriasis (Van Wyk and Wink, 2014; Bone and Mills, 2013; Khare, 2007, 2016). Bylka et al. (2014, 2013) mention that Gotu Kola is effective in improving treatment of small wounds, hypertrophic wounds as well as burns, psoriasis and scleroderma. For this reason, this plant has various potential applications in modern cosmetology.
The plant has been used in India as a contraceptive and animal studies have shown that certain bioactive compounds in the plant possess anti-fertility effects (Bone and Mills, 2013). The boiled leaves are eaten for urinary tract infections and the unfiltered juice from the plant is drunk for scrofula and syphilis (Khare, 2007).
The main active ingredients in Gotu Kola include triterpene saponins, also known as centellosides, such as medacassoside and asiaticoside (also known as asiatic acid). A study by Sirichoat et al. (2015) investigated the relationship between spatial working memory and changes in cell proliferation within the hippocampus after administration of asiatic acid to male Spraque-Dawley rats. The results of the study showed that asiatic acid treatment may potentially be a potent cognitive enhancer which improves hippocampal-dependent spatial memory, presumably by augmenting hippocampal neurogenesis
Flavonoid compounds and sesquiterpenoids are also present. The triterpenoid compounds act as spindle poisons during the metaphase of the cell cycle and prevent cell division (Van Wyk and Wink, 2014; Bone and Mills, 2013). However, Chandrika and Prasad Kumarab (2015) mention that there are only limited detailed scientific clinical trials regarding the health benefits and nutritional value of this plant, as this precludes learning more about its benefits, mechanisms, and possible toxicity.

Safety / Precautions

  • There is one report of acute liver failure in a 15-year-old child who took an herbal product bought over the Internet that presumably contained Gotu kola (Dantuluri et al., 2011).
  • Its use in pregnancy has not been thoroughly investigated (Gardner and McGuffin, 2012). For this reason, it may be best to avoid the plant, especially during the first trimester of gestation
  • The plant is considered in Indian traditional medicine to be compatible with breastfeeding
  • Gotu Kola may cause an allergic reaction in rare cases
  • Prolonged and excessive use of the plant may cause side effects (Van Wyk and Wink, 2014).
  • It is important to use only herbs that have undergone strict quality control in order to avoid possible contamination with heavy metals and other potential toxicants (Nema et al., 2014).

Before you decide to take any medicinal herb or herbal supplement, be sure to consult with a health care professional first. Avoid self-medication and self-diagnosis: Always be on the safe side!

References:

Bone K, Mills S. Principles and Practice of Phytotherapy 2nd Ed.
London: Churchill Livingstone; 2013; pp. 284-285.

Bylka W, Znajdek-Awiżeń P, Studzińska-Sroka E, Dańczak-Pazdrowska A, Brzezińska M. Centella asiatica in dermatology: an overview. Phytother Res. 2014; 28(8):1117-24. doi: 10.1002/ptr.5110.

Bylka W, Znajdek-Awiżeń P, Studzińska-Sroka E, Brzezińska M. Centella asiatica in cosmetology. Postepy Dermatol Alergol. 2013; 30(1):46-9. doi: 10.5114/pdia.2013.33378.

Chandrika UG, Prasad Kumarab PA. Gotu Kola (Centella asiatica): Nutritional Properties and Plausible Health Benefits. Adv Food Nutr Res. 2015;76:125-57. doi: 10.1016/bs.afnr.2015.08.001.

Dantuluri S, North-Lewis P, Karthik SV. Gotu Kola induced hepatotoxicity in a child - need for caution with alternative remedies. Dig Liver Dis. 2011; 43(6):500. doi: 10.1016/j.dld.2010.12.012.

Gardner Z, McGuffin M (Editors). Botanical Safety Handbook 2nd ed.
Boca Raton, FL; CRC Press; 2013; pp. 123-124.

Khare C P. Ayurvedic Pharmacopeial Plant Drugs.
Boca Raton, FL: CRC Press; 2016; pp. 89-90.

Khare C P. Indian Medicinal Plants: An Illustrated Dictionary.
New Delhi, India: Springer-Verlag; 2007; pp. 136-137.

Khare C P. Indian Herbal Remedies.
Berlin: Springer-Verlag; 2004; pp. 138-139.

Mendoza-Castelán G, Lugo-Pérez R. Plantas Medicinales en los Mercados de México.
Chapingo, Estado de México; Universidad Autónoma Chapingo; 2011; pp. 278-279.

Nema NK, Maity N, Sarkar BK, Mukherjee PK. Determination of trace and heavy metals in some commonly used medicinal herbs in Ayurveda. Toxicol Ind Health. 2014; 30(10):964-8. doi: 10.1177/0748233712468015.

Quattrocchi, U. World Dictionary of Medicinal and Poisonous Plants (4 vols.).
Boca Raton, FL: CRC Press; 2012; pp. 181-183.

Sirichoat A, Chaijaroonkhanarak W, Prachaney P, Pannangrong W, Leksomboon R, Chaichun A, Wigmore P, Welbat JU. Effects of Asiatic Acid on Spatial Working Memory and Cell Proliferation in the Adult Rat Hippocampus. Nutrients. 2015; 7(10):8413-23. doi: 10.3390/nu7105401.

Van Wyk E, Wink M. Phytomedicines, Herbal Drugs, and Poisons.
Chicago, IL: University of Chicago Press: 2014; p. 132.

Vohora D, Vohora S. Safety Concerns for Herbal Drugs.
Boca Raton, FL: CRC Press; 2016; pp. 31, 78.